Slender Fx - Weight Loss - More On Leptin

Leptin was discovered to be the controlling hormone in weight gain and loss. After years of study, DR Wallach (of Dead Doctors Don't Lie " fame )teamed up with researchers from the University of Minnesota to discover a combination of safe nutrients that assists in balancing leptin and helps the body use fat as energy instead of storage. In addition, huge benefits have been seen for Diabetics, Heart Patients, Cancer Patients plus Children !

Time Magazine, CNN, Harvard University and many more all say that Leptin is the key to weight loss. The more leptin you produce, the thinner you are, these are the facts.

Rising Obesity Rates Annihilate Previous Life Span Forecasts
Americans' life expectancy already falls more than 20 years behind other developed countries; and with U.S. obesity rates on a steady incline, the years may be further trailing.
Based on researchers' calculations, by the middle of this century the increased risk of diabetes, heart disease and cancer (faced by today's obese youth in particular) could lower the average life expectancy of 77.6 years by as much as five years. That's certainly a far cry from the 2002 Social Security Administration forecast that projected the maximum human life span to reach 100 in roughly six decades. Even more disheartening: The dramatic increase in childhood obesity may have erased anywhere from four to nine months off children's lives already, according to researchers.

Today's Trends, Tomorrow's Reality
Instead of making longevity predictions based on historical trends in death rates, the team of researchers projected future rates by examining today's younger generation. They compared the death rates of obese people to those of healthy weight people. Yet even if the life span calculations made are not perfect, explained one obesity researcher, the emphasis the study places on obesity dangers should serve as an "eye-opener" for policy makers and the public health community.

The current obesity statistics are mind-blowing!

New England Journal of Medicine March 17, 2005, Volume 352, Number 11:1138-1145
ABC News March 16, 2005
Nature.com March 17, 2005

Research has turned up some surprising insights into how the toxicity of fat itself might be causing obesity-related deaths. For many years, experts have attributed extra weight and strain on the heart as the explanation to why people are dying at young ages. However, while extra weight has been a contributor to conditions such as sleep apnea and arthritis, it's a small factor compared to the damage done by the globs of fat spread all over the human body.
Recent discoveries suggested that fat-holding cells generated a mix of hormones and other chemical messages that regulated the energy balance of the body. When churned out in large amounts by cells filled to the maximum with fat, they attacked several organs in ways that negatively affected health. These findings also suggested that fat tissues were active manufacturers of signals to various parts of the body. This discovery was first made 10 years ago on the substance leptin, which scientists found helped maintain fat through the production of a chemical, which regulates the appetite. Experts now view fat tissue as the largest endocrine organ in the body.

The "obesity hormone" Leptin appears to reduce cravings for sweet foods by targeting taste receptors on the tongue. Therefore, it is possible that a lack of leptin, or the body's failure to respond to the hormone due to defects in leptin receptors, may contribute to the so-called 'sweet tooth' that affects so many people.
Leptin, a hormone produced by fat cells, is involved in weight regulation. It is thought that the hormone signals the brain when fat cells are "full," but exactly how the hormone controls weight is not entirely clear.
The findings suggest that the tongue "is a...target for leptin, and that leptin may be a sweet-sensing modulator (suppressor) that may take part in regulation of food intake," Dr. Kirio Kawai of Tokyo Medical and Dental University in Japan, and colleagues report.
The results may explain why obese animals and humans without leptin, or with defective leptin receptors, become obese.
Variation in leptin, or leptin receptors, may determine why some people are more likely to eat calorie-rich sweet foods. Although prior studies have found that obese individuals often have too much, not too little leptin, they may have lost their sensitivity to the hormone and become leptin-resistant, in the same manner as so many people become insulin resistant.
To investigate the effects of leptin on taste buds, researchers injected a group of healthy mice with leptin and gauged their reactions to sweet, salty, sour, and bitter substances. The mice were less interested in sweet tastes such as sucrose and saccharin after the injection but their reactions to other tastes were unaffected.
In another part of their experiment, a separate group of mice were bred to become diabetic and to have defective leptin receptors on their cells. These mice did not appear to be less interested in sweet foods even after they were injected with the hormone.

Scientists had more bad news for couch potatoes saying they had found that exercise can lower the levels of a "fat hormone" in the body -- no matter how fat a person is. Their findings add to a growing body of evidence that nothing works better than hitting the pavement to prevent diabetes and heart disease. The team, at the Harvard School of Public Health in Boston, found that, fat or thin, men who exercised the most had lower levels of leptin in their blood.
If you get more exercise, you can lower your leptin levels, even if your BMI stays the same. BMI stands for body mass index, and is used by researchers around the world to calculate obesity. Scientists have been intrigued since the hormone leptin was discovered, and became excited when they found that injecting leptin into rats could cause them to lose weight.
Sadly, the same is not true for humans. In fact, overweight people have higher levels of leptin than lean people do, which suggests the hormone, which controls appetite in rodents, is being overproduced by the body for some reason. Five years ago, it was believed that leptin research might offer a miracle solution to obesity and the many health problems associated with being overweight.
As you get fatter, your body makes more leptin. But when you exercise, the amount of leptin in the blood decreases. Most of the time, you also lose weight, which means your risk of heart disease decreases too.
The researchers looked at the dietary and lifestyle habits of 268 men aged 47 to 83. None of the men had heart disease, diabetes or cancer. Men whose leptin levels were the highest weighed more, exercised the least and ate more foods high in saturated fat and cholesterol. The researchers also found evidence that the fattest men were starting a tendency toward diabetes -- which in the early stages is marked by an increased production of insulin.
Men whose bodies produce more insulin also tend to have increased leptin levels. This would suggest that leptin might play a role in diabetes. It is too early to say whether leptin levels could be used to predict a person's risk of heart disease. But obesity raises a person's risk of a heart attack and stroke, and our findings provide evidence that physical activity may reduce the chronic disease risk in men through changes in leptin levels.
Meeting of the American Heart Association in San Diego March 3, 2000

Insulin Receptors in Brain Tied to Appetite and Weight Gain
Insulin receptors in the brains of mice are involved in appetite, weight gain and fertility, new research has shown.

When researchers "knocked out" insulin receptors in the brains of genetically altered mice, they discovered that the animals ate more, put on fat, had fertility problems, and developed insulin resistance throughout the body -- a precursor to diabetes in humans.
Insulin is a key hormone in metabolism, and its levels rise as levels of body fat rise.
Although obese people often have chronically high insulin levels, they often become or are already resistant to the hormone and eventually develop diabetes.
While it is well known that tissue such as muscle and fat can become insulin resistant, it had been assumed previously that the brain is not sensitive to insulin.
This study, however, confirms earlier evidence that insulin receptors in the brain help control food intake and body weight.
The fact that knocking out the brain's insulin receptors triggered infertility in the mice was something of a surprise finding to many. The mice showed increased levels of the "obesity hormone" leptin, as well. Leptin is believed to help the body regulate fat, perhaps through triggering feelings of satiety.
Leptin resistance </2000/oct/1/leptin_sugar.htm> has also been linked to obesity, as noted in another article this week. One researcher proposed that it is possible that insulin resistance and leptin resistance act together in the onset of obesity and diabetes.

Leptin is a product of the obese gene. It is a protein hormone that affects the regulation of body weight and metabolism. Leptin is produced by fat tissue and is secreted into the bloodstream where it travels to the brain and other tissues. Leptin causes fat loss and decreased appetite and plays a very important role in calorie intake and calorie burning. There have been years of studies done on Leptin and they have all had very interesting results. Studies have shown that while receiving Leptin, subjects ate less and had an increase in their energy use. Many researches feel that Leptin gives new clues to why weight control is so difficult for some people. Leptin causes you to lose stored fat; regular dieting robs the body of both fat and muscle. When you diet, your body compensates for reduced calorie and fat intake by lowering your energy and metabolism. Leptin can actually increase your energy and metabolism. learning more about the leptin diet Just like everything else, some people are more susceptible to having problems with their natural Leptin levels than others. Many people who try to lose weight can find it difficult, even if they eat smaller portions and exercise. This can be due to their Leptin levels and regulating these levels will end their battle with the scale. But for some it is not that simple, Leptin will not help everyone lose large amounts of weight. For some people it's just simply poor nutrition and lack of exercise. The best diet and exercise plan in the world won't work unless the Leptin levels are correct. There are several signs that can tell you if you have a problem with your Leptin levels. These include: Uncontrollable cravings, especially sugar Late night eating Stress eating Weight gain around the middle Inability to reach a goal weight Yo-yo dieting Low thyroid symptoms If you have constant problems controlling your weight- you lose and gain only to remain basically the same size - or show some of the symptoms listed above, you may have a problems with you Leptin levels. But there is something you can do about it. Although Leptin is not available and is not on the market yet, you can balance you body, regulate your hormones, and provide the right nutrition so your body increases its own production of Leptin. there is an answer, Slender Fx Weight loss can be very difficult for individuals with Leptin problems, but with Slender Fx you can balance your Leptin levels. Slender Fx opens the door for a healthy metabolism, permanent weight loss, reduction of low thyroid symptoms, and considerably increased energy. You can finally lose weight safely. It can be very overwhelming to realize that you have wasted years and thousands of dollars on fad diets, gym memberships, and "magic" diet pills when all you needed to do was to put your body in the correct balance. After you have suffered through depression, self-doubt, humiliation, and hundreds of other emotions only to realize that it wasn't your fault after all. It's an imbalance in your system that can be corrected in a few short weeks. Insulin, estrogen, testosterone, growth hormone, cortisone, and even brain chemicals all have an effect on increasing and decreasing the balance of Leptin in the body. With Slender Fx you can get your body in balance and put your appetite on the level where it needs to be. With Slender Fx, you can put your metabolism on the level it needs to be on, and with Slender Fx you can reset your "set" body size. clinical facts about the Slender Fx solution Scientists from St. Lukes-Roosevelt Hospital in New York City gave Leptin to a group of subjects and those who took Leptin lost more weight than the control group, and the largest amount of weight loss was in the group that was given the highest doses. But more importantly, most of the weight that the subjects lost was fat, (most weight loss is usually 75% fat and 25% muscle) New studies suggest that Leptin can change the areas that control appetite in the brain. Leptin can also possibly be influencing babies and determining how they eat as adults. Recently researcher Roger Unger showed that Leptin turns fat-storing cells into fat-burning cells in mice with the help of his colleagues at the University of Texas, Southwestern Medical Center at Dallas. Howard Hughes Medical Institute researchers at The Rockefeller University recently discovered that the appetite-regulating hormone Leptin can be the cause of rewiring neurons in areas of the brain that control feeding behavior. "The wiring diagram of the system that regulates feeding may be different in the obese than in the lean, and that may explain why lifestyle changes aren't generally effective for achieving substantial weight loss over the long term,"- Jeffrey Friedman Howard Hughes Medical Institute at Rockefeller University Leptin is produced by fat tissue and secreted into the bloodstream, where it travels to the brain and other tissues, causing fat loss and decreased appetite.

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